Polynucleotides

Polynucleoltides  (PN) are an injectable skin treatment which is designed to help tissue repair. It improves skin quality, thickness, hydration, and promotes new collagen formation.

What are polynucleotides?

Advertisement for Mastelli polynucleotide skincare products, featuring boxes labeled 'Newest', 'Plinest', and 'One', with a backdrop of a DNA helix and clouds.

This polymerised, polynucleotide-based injectable gel works by stimulating fibroblasts, encouraging cell turnover, improving elasticity, boosting collagen production and hydrating the skin.

Polynucleotides have a host of potential applications, including treatment for acne scarring, hyperpigmentation, and rosacea as well as the signs of ageing. They are also very effective in treating hair restoration and growth.

Often we can combine polynucleotide treatments with platelet rich plasma (PRP)

In addition to treatments for the  scalp, upper, mid and lower face, Polynucleotides  can also be used to treat the neck, décolletage, inner arms, thighs, and knees. It is also particularly useful for difficult areas such as the neck and beneath the eyes.

Box of skincare product labeled 'Newest' with polynucleotides, hyaluronic acid, and lactic acid, branded by Mastelli.

Suitable for:

  • Geometric drawing of an outline square with sections divided by vertical, horizontal, and diagonal lines.

    Frown lines

  • Geometric drawing of an outline square with sections divided by vertical, horizontal, and half circle lines.

    Forehead lines

  • Geometric drawing of an outline square with sections divided by vertical, horizontal, and circle lines.

    Crows feet

  • Geometric drawing of an outline square with sections divided by vertical, horizontal, and diagonal lines.

    Bunny/nose lines

  • A black cat with yellow eyes looking directly at the camera, lying on a white surface, with a yellow fruit behind it.

    Smokers lines

  • A black and white line drawing of a person walking a dog on a leash.

    Sad mouth

  • A black silhouette of a cat sitting and looking to the right, with a curved tail.

    Pebble chin

  • Black and white icon of a microphone.

    Jaw grinding

  • A silhouette of a person sitting cross-legged, meditating on a large rock with a mountainous landscape in the background during sunset.

    Nefertiti neck lift

Before & after

Side-by-side comparison of the same person's skin, showing improvement in skin texture and reduction of wrinkles.

Research and clinical evidence

Research studies have shown the following effects:

  • 115% increase in skin hydration

  • Over 50% increase in skin thickness

  • 47% increase in collagen production

  • 38% increase in skin elasticity

  • Reduction in inflammatory redness and improvement in rosacea and acne

  • Improvement in acne scarring

  • Reduction in pigmentation resulting from sun exposure

  •  PNs can help stimulate hair follicles, increase blood flow to the scalp, and promote the growth of thicker, healthier hair. A study published in the Journal of Dermatology and Clinical Research highlighted the potential of polynucleotides in improving hair density and overall hair quality.

Pain: Mild- moderate

Social Downtime: 24-72 hours, potential for bruising

Results: Are seen within 3 weeks

Recommended course: 3 treatments 28 days apart, then maintenance 6-12 months

Treats: Aging skin, fine lines, wrinkles

Cost: From £250